Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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Pathology Image
  • SPECIES:
    • FELINE
  • SYSTEM:
    • HEMATOPOIETIC
  • ORGAN:
    • BONE-MANDIBLE
  • DIAGNOSIS:
    • MANDIBLE AND MANDIBULAR TEETH: PORPHYRIN PIGMENTATION, DIFFUSE, SEVERE
  • CONTRIBUTOR:
    • METRO
  • INSTITUTION:
    • The Ohio State University
  • GENPATH:
    • PIGMENTATION
  • COMMENTS:
    • Congenital erythropoetic porphyria is a hereditary disease seen in catsresulting from a lack of uroporphyrinogen-3 cosynthetase, which is required for formation of the hemoglobin molecule. Animals which are deficient in this enzyme have high levels of a uroporphyrin I in the serum, which results in a range of effects from pigmentation of bone and teeth as seen here (there is no associated histologic defect), photosensitization, and in some species, including the cat, moderate hemolytic anemia.