Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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  • SPECIES:
    • FELINE
  • SYSTEM:
    • INTEGUMENT
  • ORGAN:
    • FOOTPAD
  • DIAGNOSIS:
    • PLASMA CELL PODODERMATITIS
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • JOINT PATHOLOGY CENTER
  • GENPATH:
    • IMMUNE DYSFUNCTION
  • COMMENTS:
    • Feline plasma cell pododermatitis is a rare disease of unknown pathogenesis. It is clinically characterized by soft and spongy swelling of multiple foot pads. Breed, age, or sex predilections have not been noted. The central metatarsal and metacarpal pads are most consistently involved. The lesion is generally painless but lameness may develop secondary to ulceration and extensive hemorrhage. The cause and pathogenesis of feline plasmacytic pododermatitis are still unknown however, the marked plasma cell infiltrate, consistent hypergammaglobulinemia and response to immunosuppressive (i. e. glucocorticoids) or immunomodulating (i. e. tetracyclines) therapy suggests an immune dysfunction. In some cats concurrent plasmacytic stomatitis, renal amyloidosis or immune-mediated glomerulonephritis have been reported .