- SPLENIC LYMPHOID HYPERPLASIA
- Armed Forces Institute of Pathology
- There is diffuse hyperplasia of splenic lymphoid tissue. The white foci are all approximately the same size and same intensity of color, as opposed to what you might see in a bacterial infection with splenic abscesses, which would be of different sizes and varying intensity (large resulting from temporal differences in their formation). Splenic lymphoid hyperplasia is less prevalent than nodal inflammation as it tends to require systemic, intense and or prolonged antigenic stimulation. Another important cause would be lentivirus infection in cats and other species (cattle, NHP, and humans). Lentiviruses like HIV, SIV, and FIV begin their assault on the immune system with a marked hyperplasia of lymphoid tissue (you need lots of cells to infect to establish a good infection) before there is severe widespread lymphopenia.