- PERICARDIAL MESOTHELIOMA
- Armed Forces Institute of Pathology
- MINERALIZATION, CALCIFICATION/FOREIGN BODY/HEMORRHAGE
- Mesothelioma is a rare neoplasm in domestic animal species Based on their immunohistochemical profile, mesotheliomas are believed to arise from proliferating multipotent subserosal progenitor cells which are immunopositive for both vimentin and cytokeratin. Undifferentiated mesothelial cells are immunopositive for vimentin but not cytokeratin and terminally-differentiated surface mesothelium is immunopositive for cytokeratin but not vimentin. Several histological subtypes have been categorized: epithelial, spindle and mixed. To our knowledge, histologic subtype has not been found to be prognostically significant. Biological behavior of pericardial mesotheliomas is similar to mesotheliomas that arise in the pleura and peritoneum in that they spread via transplantation, local extension and regional metastasis. Asbestos exposure, similar to humans has been proposed but not proven as a cause in animals living in urban enviromnents.