Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

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Image: F30334

Pathology Image
  • SPECIES:
    • CANINE
  • SYSTEM:
    • HEPATOBILIARY SYSTEM
  • ORGAN:
    • LIVER
  • DIAGNOSIS:
    • BILIARY CARCINOMA
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • Armed Forces Institute of Pathology
  • GENPATH:
    • NEOPLASIA
  • COMMENTS:
    • On gross inspection, this could be either a primary or metastatic neoplasm to the liver. The umbilicated nature of the masses strongly suggests an epithelial origin, as carcinomas incite a profound desmoplastic response. In the central, older parts of the neoplasm the collagen that is laid down will contract first, resulting in a concavity to this part of te tumor. Determination as to whether this is a primary tumor of the liver - a biliary carcinoma, or simply foci of metastasis of a carcinoma in another location, such as a mammary carcinoma, will, in the absence of an obvious primary neoplasm elsewhere, will likely require histology. And, if all you get is a piece of the liver, and nothing else as a submission, be prepared to utilized immunohistochemical stains like cytokeratin 7 to try to establish that it is indeed biliary in origin. It is not always as easy as it sounds, as the liver is a common site of carcinoma metastatis, especially poorly-differentiated ones.