Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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  • SPECIES:
    • CANINE
  • SYSTEM:
    • HEPATOBILIARY SYSTEM
  • ORGAN:
    • LIVER
  • DIAGNOSIS:
    • PORTAL VEIN THROMBUS
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • Armed Forces Institute of Pathology
  • GENPATH:
    • THROMBUS, thrombi
  • COMMENTS:
    • There are four important causes of thrombosis (excluding Virchow's triad, which is a differen discussion). These are severe glomerular disease (glomerulonephritis and amyloidosis) in which antithrombin is lost in he urine; pancreatitis, excessive corticosteroids (they inhibit tissue plasminogen) and neoplasia (both primary and metastatic forms). In cases of rampant intravascular thrombosis, like DIC, remember that the clotting and anti-clotting systems generally work in concert, so thrombi are being formed and dissolved at the same time. If you are lucky, you may see infarcts at autopsy to let you know which areas to incise first.