Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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Pathology Image
  • SPECIES:
    • NHP - SPIDER MONKEY
  • SYSTEM:
    • SKELETAL
  • ORGAN:
    • BONE-SKULL
  • DIAGNOSIS:
    • CEPHALOHEMATOMA WITH OSSIFICATION
  • CAUSE:
    • VITAMIN C DEFICIENCY
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • Armed Forces Institute of Pathology
  • GENPATH:
    • NUTRITIONAL\VITAMIN DEFICIENCY
  • COMMENTS:
    • This is a classic lesion of scurvy in squirrel monkeys. Deficiency of vitamin C, an essential co-factor of lysyl and proline hydroxlases, which are required for proper crosslinking of collagens 1 and 4. Collagen type 4 is the major collagen within blood vessels, so the vessels leak. Squirrel monkeys have a predilection to form hematomas on top of their heads. When proper levels of Vitamin C are restored, these hematomas may ossify, resulting in misshapen skulls.