- NHP - SPIDER MONKEY
- CEPHALOHEMATOMA WITH OSSIFICATION
- VITAMIN C DEFICIENCY
- Armed Forces Institute of Pathology
- NUTRITIONAL\VITAMIN DEFICIENCY
- This is a classic lesion of scurvy in squirrel monkeys. Deficiency of vitamin C, an essential co-factor of lysyl and proline hydroxlases, which are required for proper crosslinking of collagens 1 and 4. Collagen type 4 is the major collagen within blood vessels, so the vessels leak. Squirrel monkeys have a predilection to form hematomas on top of their heads. When proper levels of Vitamin C are restored, these hematomas may ossify, resulting in misshapen skulls.