Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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Pathology Image
  • SPECIES:
    • NHP - RHESUS
  • SYSTEM:
    • GASTROINTESTINAL
  • ORGAN:
    • ORAL CAVITY
  • DIAGNOSIS:
    • MULTIFOCAL TO COALESCING ULCERATIVE CHEILITIS AND GLOSSITIS
  • CAUSE:
    • MACACINE HERPESVIRUS-1
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • Armed Forces Institute of Pathology
  • GENPATH:
    • VIRAL
  • COMMENTS:
    • Macacine herpesvirus 1 (MHV-1) is an alphaherpesvirus that causes subclinical to mild disease in macaques, but can cause widespread disease in immunsuppressed macaques and fatal encephalitis in humans. The disease for a long time was called B virus, after its first documented victim, Dr. William Brabner who was bitten by a macaque while researching poliomyelitis in Dr. Jonas' Salk's laboratory. The virus may be spread by inapparently latent monkeys by saliva or aerosolized respiratory droplets, scratches or bites. There is no good blood ts for the virus, as like most alphaherpesvirus, it becomes latent within nerves and ganglia until recrudescence of disease. For this reason, all macaques should be considered to be carriers of the virus during all interactions.