- HEPATOBILIARY SYSTEM
- MULTIFOCAL TO COALESCING HEPATIC NECROSIS
- CLOSTRIDIUM PILIFORME
- Armed Forces Institute of Pathology
- In the foal, lesions of the enteron, which normally precede hepatic necrosis, have not yet been identified. All cases of Tyzzers disease manifest as multifocal to coalescing areas of hepatocellular necrosis with intracytoplasmic bacilli, and the vast majority are fatal. Foals are thought to be infected by eating the feces of the mare, a behavior that helps establish normal gut flora; however, some mares have elevated numbers of C. piliforme in the gut as a result of increased carbohydrate feeding in the postpartum period.