- GUINEA PIG
- MULTIFOCL TO COALESCING PERIARTICULAR HEMORRHAGE
- VITAMIN C DEFICIENCY
- Armed Forces Institute of Pathology
- This is a cliassic lesion of Vitamin C deficiency in suceptible animal species (those that don't have the enzume gulonolactone oxidase, which allows them to make Vitamin C). These species include the guinea pig, primates, fish, and some species of birds and bats. Vitamin C is an essential cofactor of the enzymes proline and lysyl hydroxylase which are required for the proper cross-linking of Type I and IV collagen. Type IV collagen is the primary collagen of blood vessels, and Vitamin C deficiency results in hemorrhage, most often around joints (which are themselves damaged by impaired Type 1 collagen). Hemorrhage is also often seen around loosened teeth.