Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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Image: F30177

Pathology Image
  • SPECIES:
    • BOVINE
  • SYSTEM:
    • NERVOUS
  • ORGAN:
    • CEREBELLUM
  • DIAGNOSIS:
    • 1. MARKED CEREBELLAR HYPOPLASIA 2. HYDROCEPHALUS EX VACUO.
  • CAUSE:
    • BOVINE PESTIVIRUS
  • CONTRIBUTOR:
    • STEINBERG
  • INSTITUTION:
    • University of Wisconsin
  • GENPATH:
    • VIRAL
  • COMMENTS:
    • Infection of calves between days 75 and 170 of gestation can result in severe congenital defects of the nervous system. The most common is cerebellar hypoplasia, as seen here. Viral infection occurs in the external germinal cell layer which lies immediately under the meninges and gives rise to the neurons of the granular cell layer and to a lesser extent, the Purkinje cell layer. This image also demostrates bilateral cconcavity of the occipital lobes, likely as a result of hydrocephalus ex vacuo. In the cerebrum, the germinal cell layer surrounds the ventricles, and may be infected by bovine pestivirus as well. The loss of these germinative neurons will result in the decreased formation of cerebral neurons and their processes, decreased mass of the cerebrum, and ultimately dilation of the ventricles to take up the excess space (hydrocephalus ex vacuo).