Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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  • SPECIES:
    • OVINE
  • SYSTEM:
    • NERVOUS
  • ORGAN:
    • BRAIN
  • DIAGNOSIS:
    • BILATERAL THALAMIC HEMORRHAGE AND NECROSIS
  • CAUSE:
    • CLOSTRIDIUM PERFRINGENS D
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • Armed Forces Institute of Pathology
  • GENPATH:
    • CARBON, PNEUMOCONIOSIS
  • COMMENTS:
    • Clostridium perfringens type D results in necrotizing enteritis, and subsequent absorption of the epsilon toxin into the bloodstream. A characteristic finding is encephalomalacia, as well as hemorrhages in many organs. In the brain, it characteristically results in bilaterally symmetrical hemorrhage and necrosis of the white matter of the thalamus, cerebellar peduncles and corpus striatum. A recent article by Uzal et al. describes intramural edema of cerebral vasculature. Hemorrhage are seen in many organs. Newborns lack enzymes to activate epsilon toxin so are not effected by the toxin.