Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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Image: F28780

Pathology Image
  • SPECIES:
    • BOVINE
  • SYSTEM:
    • NERVOUS
  • ORGAN:
    • CEREBELLUM
  • DIAGNOSIS:
    • CEREBELLAR HYPOPLASIA WITH CEREBRAL PORENCEPHALY AND HYDROCEPHALUS
  • CAUSE:
    • BOVIEN PESTIVIRUS
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • Armed Forces Institute of Pathology
  • GENPATH:
    • VIRAL
  • COMMENTS:
    • Cerrebellar hypoplasia is a classic lesion associated with pestivirus infection in utero - infection of the external granular layer, which gives rise to the granular cell layer and to a lesser extent, the Pukinje cell layer. This window is open for a long time, as full developement of the cerebellum occurs late in the gestation periond (and up to 2 week after birth in some species, such as cats.) Now there is also a focus of porenchephaly here in the anterior occipital lobe suggesting early infection, and subjectively, there is hydocephalus (likely ex vacuo) suggesting dimished cerebral development following infection of the periventricular stem cells. This picture likely represents infection late enough in gestation not to kill the fetus, but to cause significant maldevelopment of neural tissue.