Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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Image: F28640

Pathology Image
  • SPECIES:
    • MOUSE
  • SYSTEM:
    • REPRODUCTIVE
  • ORGAN:
    • MAMMARY GLAND
  • DIAGNOSIS:
    • MAMMARY CARCINOMA
  • CAUSE:
    • MOUSE MAMMARY TUMOR VIRUS
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • Armed Forces Institute of Pathology
  • GENPATH:
    • NEOPLASIA
  • COMMENTS:
    • Mouse mammary tumor virus is betaretrovirus which as incorporated into the genome of a number of strains of mice. In the 1930's it was identified as the "milk facotr" or "Bittner agent" and transmitted horizontally through milk, but today, vertical transmssion is the primary mode of transmission through the germline. When inserted in the DNAnear an oncogene, it will activate the oncogene and cancer results. It may also insert in "silent areas of the genome inciting no diseases or rarely other diseases. While the mammary neoplasms in rats are primarily benign, they are malignant in the mouse.