Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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Image: F28456

Pathology Image
  • SPECIES:
    • GUINEA PIG
  • SYSTEM:
    • CARDIOVASCULAR
  • ORGAN:
    • JOINT-STIFLE
  • DIAGNOSIS:
    • STIFLE HEMORRHAGE; VITAMIN C DEFICIENCY
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • Armed Forces Institute of Pathology
  • GENPATH:
    • NUTRITIONAL\VITAMIN DEFICIENCY
  • COMMENTS:
    • Vitamin C deficiency is a disease of only species that lack l-gulonolactone - the enzyme that allows for the synthesis of vitamin C (ascorbic acid). Primates (and humans), fish, guinea pigs, fruit bats and some species of birds lack this enzyme and are susceptible to deficiency of Vitamin C. Vitamin C is a cofactor of many enzymes, including proline and lysine hydroxylase, which are essential in the production and cross linking of collagen type I and type 4. Collagen type 4 is the primary form of collagen in the walls of vessels - defects result in hemorrhage, especially at joints and pressure points of affected guinea pigs. Collagen type 1 is the collagen of bones, joints and teeth - affected animals often exhibit pain on movement (but this cannot be discerned in this picture.) Vitamin C deficiency results in significant damage to the growth plate in young animals, and classical signs of scurvy.