Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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Pathology Image
  • SPECIES:
    • EQUINE
  • SYSTEM:
    • NERVOUS
  • ORGAN:
    • CEREBRUM
  • DIAGNOSIS:
    • LEUKOENCEPHALOMALACIA
  • CAUSE:
    • FUMONISIN B1
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • Armed Forces Institute of Pathology
  • GENPATH:
    • TOXICOLOGIC
  • COMMENTS:
    • Fumonisin B1, produced by the saprophyte Verticilloides moniforme which grows in moldy grain, causes hemorrhage and necrosis within the cerebral white matter. The mechanism is the inhibition of sphingosine by the toxin which results in endothelial dysfunction.