Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869

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Pathology Image
  • SPECIES:
    • CANINE
  • SYSTEM:
    • URINARY
  • ORGAN:
    • URINARY BLADDER
  • DIAGNOSIS:
    • NECROTIZING AND HEMORRHAGIC CYSTITIS
  • CAUSE:
    • CYCLOPHOSPHAMIDE
  • CONTRIBUTOR:
    • WILLIAMS
  • INSTITUTION:
    • Armed Forces Institute of Pathology
  • GENPATH:
    • TOXICOLOGIC
  • COMMENTS:
    • Sterile cystitis is the most common and dose-dependent sequelae of cyclophophamide chemotherapy. Acrolein, the toxic principle, directly damages the bladder mucosa. Symptoms may be seen during or following the course of treatment. Diuresis with or without concurrent 2 mercaptoethane sulphone sodium administration may lessen the incidence of dogs under treatment.